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The early production stages of Hydrochloride Chlortetracycline ("HCL CTC") and feed-grade Chlortetracycline ("FG CTC") are almost the same where a process of fermentation is needed. The fermented broth would then be piped into an acidification barrel along with oxalic acid and hydrochloride acid being added to it for the next process which is the acidification. A series of filtrations would then be followed before magnesium chloride and calcium carbonate are added to the filtrated broth to carry out the double-salt process. |
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The crystallization process begins after the acidification, salting, crude crystallization and dissolving processes. After the filtrated broth in the filter plate is transported to the double-salt tanks and crude crystal tanks, by crystallization and a series of filtrating and dissolving processes, the HCL CTC content in the broth becomes higher. The refined broth is then transported to the Hydrochloride crystal tanks to complete its final stage of crystallization. |
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Like FG CTC, the crystallized HCL CTC needs drying. However, before drying takes place, it will first go through a vacuum-filtration process, followed by a rinsing process where ethanol and pure water are added into the centrifuge. After these processes are completed, it is then oven-dried. Via a mixer, different purities of HCL CTC would be blended together and packaged into finished products with different gradings.
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The finished products of HCL CTC are then passed on for inspection. To ensure high quality and purity of the products, inspection tests such as chemical tests, biological tests, HPLC tests and stability tests are conducted. When all the required tests are passed, the finished products are then packaged for delivery.
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